[an error occurred while processing this directive]

Application of gabapentin in the treatment of hemodialysis patients 

  • LI Qing-Lei
Expand
  • 1Changle Weigao Hemodialysis Center, Changle District, Fuzhou City, Fujian Province,Changle 350000,China ;   2Department of Nephrology, 960th Hospital of Chinese People's Liberation Army,Jinan 250031, China

Received date: 2022-02-28

  Revised date: 2022-05-31

  Online published: 2022-09-06

Abstract

With the higher prevalence and the longer survival of uremia patients in our country, the shortage of hemodialysis professionals prevails and accounts for the insufficiency of hemodialysis technologies in basic communities. The advanced assistant dialysis measures, such as high flux hemodialysis, hemoperfusion and drugs of expensive prices, are hardly to be adopted in several areas due to the different health insurance policies, causing dialysis inadequacy and hemodialysis complications in many patients in these areas. Gabapentin (GBP) has a better therapeutic effect in the treatment of many hemodialysis complications. We therefore searched the databases of PubMed and CNKI for the studies in recent years about GBP in the treatment of hemodialysis complications, including uremic pruritus, restless legs syndrome and uremic peripheral neuralgia. In this paper, we try to provide the therapeutic strategies against hemodialysis complications by using GBP for hemodialysis professionals.

Cite this article

LI Qing-Lei . Application of gabapentin in the treatment of hemodialysis patients [J]. Chinese Journal of Blood Purification, 2022 , 21(09) : 664 -667 . DOI: 10.3969/j.issn.1671-4091.2022.09.009

References

[1]Uchitel OD, Di Guilmi MN, Urbano FJ, Gonzalez-Inchauspe C. Acute modulation of calcium currents and synaptic transmission by gabapentinoids.?Channels (Austin). 2010;4(6):490-496.
[2]Razeghi E, Eskandari D, Ganji MR, Meysamie AP, Togha M, Khashayar P. Gabapentin and uremic pruritus in hemodialysis patients.?Ren Fail. 2009;31(2):85-90.
[3]Mohammadi Kebar S, Sharghi A, Ghorghani M, Hoseininia S. Comparison of gabapentin and hydroxyzine in the treatment of pruritus in patients on dialysis. Clin Exp Dermatol. 2020 Oct;45(7):866-871.
[4]Solak Y, Biyik Z, Atalay H, et al. Pregabalin versus gabapentin in the treatment of neuropathic pruritus in maintenance haemodialysis patients: a prospective, crossover study.?Nephrology (Carlton). 2012;17(8):710-717.
[5]Amirkhanlou S, Rashedi A, Taherian J, Hafezi AA, Parsaei S. Comparison of Gabapentin and Ketotifen in Treatment of Uremic Pruritus in Hemodialysis Patients.?Pak J Med Sci. 2016;32(1):22-26.
[6]Simonsen E, Komenda P, Lerner B, Askin N, Bohm C, Shaw J, Tangri N, Rigatto C. Treatment of Uremic Pruritus: A Systematic Review. Am J Kidney Dis. 2017 Nov;70(5):638-655. doi: 10.1053/j.ajkd.2017.05.018. Epub 2017 Jul 15.
[7]Eusebio-Alpapara KMV, Castillo RL, Dofitas BL. Gabapentin for uremic pruritus: a systematic review of randomized controlled trials.?Int J Dermatol. 2020;59(4):412-422.
[8]Hercz D, Jiang SH, Webster AC. Interventions for itch in people with advanced chronic kidney disease.?Cochrane Database Syst Rev. 2020;12(12):CD011393.Published2020 Dec 7.
[9]Rayner HC, Larkina M, Wang M, Graham-Brown M, van der Veer SN, Ecder T, Hasegawa T, Kleophas W, Bieber BA, Tentori F, Robinson BM, Pisoni RL. International Comparisons of Prevalence, Awareness, and Treatment of Pruritus in People on Hemodialysis. Clin J Am Soc Nephrol. 2017 Dec 7;12(12):2000-2007. doi: 10.2215/CJN.03280317. Epub 2017 Sep 18.
[10]Aquino TMO, Luchangco KAC, Sanchez EV, Verallo-Rowell VM. A randomized controlled study of 6% gabapentin topical formulation for chronic kidney disease-associated pruritus.?Int J Dermatol. 2020;59(8):955-961.
[11]Haber R, Bachour J, Salloum A, et al. Comparison of gabapentin and doxepin in the management of uremic pruritus: A randomized crossover clinical trial.?Dermatol Ther. 2020;33(6):e14522.
[12]陈秀花. 加巴喷丁对维持性血液透析尿毒症患者伴皮肤瘙痒症的疗效观察[J]. 青海医药杂志,2021,51(10):13-15.
[13]杨君,林新伟. 加巴喷丁联合氯雷他定治疗尿毒症期皮肤瘙痒的临床分析[J]. 现代诊断与治疗,2021,32(16):2566-2567.
[14]Ravindran A, Kunnath RP, Sunny A, Vimal B. Comparison of Safety and Efficacy of Pregabalin versus Gabapentin for the treatment of Uremic Pruritus in Patients with Chronic Kidney Disease on Maintenance Haemodialysis.?Indian J Palliat Care. 2020;26(3):281-286.
[15]Fishbane S, Jamal A, Munera C, Wen W, Menzaghi F; KALM-1 Trial Investigators. A Phase 3 Trial of Difelikefalin in Hemodialysis Patients with Pruritus. N Engl J Med. 2020 Jan 16;382(3):222-232.
[16]Lipman ZM, Yosipovitch G. An evaluation of difelikefalin as a treatment option for moderate-to-severe pruritus in end stage renal disease. Expert Opin Pharmacother. 2021 Apr;22(5):549-555.
[17]Razazian N, Azimi H, Heidarnejadian J, Afshari D, Ghadami MR. Gabapentin versus levodopa-c for the treatment of restless legs syndrome in hemodialysis patients: a randomized clinical trial.?Saudi J Kidney Dis Transpl. 2015;26(2):271-278.
[18]Fuzier R, Serres I, Guitton E, Lapeyre-Mestre M, Montastruc JL; French Network of Pharmacovigilance Centres. Adverse drug reactions to gabapentin and pregabalin: a review of the French pharmacovigilance database.?Drug Saf. 2013;36(1):55-62.
[19]Raina R, Krishnappa V, Gupta M. Management of pain in end-stage renal disease patients: Short review. Hemodial Int. 2018 Jul;22(3):290-296.
[20]Vangala C, Niu J, Montez-Rath ME, et al. Hip Fracture Risk among Hemodialysis-Dependent Patients Prescribed Opioids and Gabapentinoids.?J Am Soc Nephrol. 2020;31(6):1325-1334.
[21]Waddy SP, Becerra AZ, Ward JB, et al. Concomitant Use of Gabapentinoids with Opioids Is Associated with Increased Mortality and Morbidity among Dialysis Patients.?Am J Nephrol. 2020;51(6):424-432.
[22]Contreras-Mota M, Rosales-Cortés V. Hepatotoxicidad probablemente asociada a gabapentina [Hepatotoxicity probably associated with gabapentin].?Rev Med Inst Mex Seguro Soc. 2021;59(2):157-162. Published 2021 Jun 14.
[23] International Restless Legs Syndrome Study Group. 2012
revised IRLSSG diagnostic criteria for RLS. [cited 2013 AugAvailable from:http://irlssg.org/diagnostic-criteria/.
[24]Lin CH, Wu VC, Li WY, et al. Restless legs syndrome in end-stage renal disease: a multicenter study in Taiwan.?Eur J Neurol. 2013;20(7):1025-1031.
[25]Batool-Anwar S, Malhotra A, Forman J, Winkelman J, Li Y, Gao X. Restless legs syndrome and hypertension in middle-aged women.?Hypertension. 2011;58(5):791-796.
[26]Li Y, Walters AS, Chiuve SE, Rimm EB, Winkelman JW, Gao X. Prospective study of restless legs syndrome and coronary heart disease among women.?Circulation. 2012;126(14):1689-1694.
[27]Molnar MZ, Novak M, Mucsi I. Management of restless legs syndrome in patients on dialysis.?Drugs. 2006;66(5):607-624.
[28]Allen RP. Controversies and challenges in defining the etiology and pathophysiology of restless legs syndrome.?Am J Med. 2007;120(1 Suppl 1):S13-S21.
[29]de Oliveira MM, Conti CF, Valbuza JS, de Carvalho LB, do Prado GF. The pharmacological treatment for uremic restless legs syndrome: evidence-based review.?Mov Disord. 2010;25(10):1335-1342.
[30]Winkelman JW, Armstrong MJ, Allen RP, et al. Practice guideline summary: Treatment of restless legs syndrome in adults: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology.?Neurology. 2016;87(24):2585-2593.
[31]Ali M, Iram H, Nasim F, et al. Comparison of the Efficacy of Gabapentin Versus Levodopa-C for the Treatment of Restless Legs Syndrome in End-Stage Renal Disease on Hemodialysis Patients.?Cureus. 2020;12(12):e12034. Published 2020 Dec 11.
[32]刘勇,周加军,高潮清. 加巴喷丁与左旋多巴治疗血液透析患者不宁腿综合征的疗效观察[J]. 长治医学院学报,2021,35(03):188-191.
[33]赵冬梅.加巴喷丁联合血液透析滤过和血液灌流治疗尿毒症血液透析患者不宁腿综合征的临床效果[J].当代医学,2020,2635:164-166.
[34]徐新伟,潘光辉,林琳,陆萍,张晓玲. 艾灸辅助治疗并发不宁腿综合征的血液透析患者的临床效果[J]. 广西医学,2021,43(03):337-340+345.
[35]Razazian N, Azimi H, Heidarnejadian J, Afshari D, Ghadami MR. Gabapentin versus levodopa-c for the treatment of restless legs syndrome in hemodialysis patients: a randomized clinical trial.?Saudi J Kidney Dis Transpl. 2015;26(2):271-278.
[36]Ishida JH, McCulloch CE, Steinman MA, Grimes BA, Johansen KL. Gabapentin and Pregabalin Use and Association with Adverse Outcomes among Hemodialysis Patients. J Am Soc Nephrol. 2018 Jul;29(7):1970-1978.
[37]Choi MS, Jeon H, Kim HS, et al. A case of gabapentin-induced rhabdomyolysis requiring renal replacement therapy.?Hemodial Int. 2017;21(1):E4-E8.
[38]Qiu X, Tackett E, Khitan Z. A case of gabapentin overdose induced rhabdomyolysis requiring renal replacement therapy.?Clin Case Rep. 2019;7(8):1596-1599. Published 2019 Jul 11.
[39]Waddy SP, Ward JB, Becerra AZ, et al. Epilepsy and antiseizure medications increase all-cause mortality in dialysis patients in the United?States.?Kidney Int. 2019;96(5):1176-1184.
[40]Lal R, Sukbuntherng J, Luo W, et al. Clinical pharmacokinetics of gabapentin after administration of gabapentin enacarbil extended-release tablets in patients with varying degrees of renal function using data from an open-label, single-dose pharmacokinetic study.?Clin Ther. 2012;34(1):201-213.
[41]Rayner H, Baharani J, Smith S, Suresh V, Dasgupta I. Uraemic pruritus: relief of itching by gabapentin and pregabalin.?Nephron Clin Pract. 2012;122(3-4):75-79. doi:10.1159/000349943
[42]Fuhs A, Bentama D, Antkowiak R, Mathis J, Trenkwalder C, Berger K. Effects of short- and long-term variations in RLS severity on perceived health status - the COR-study.?PLoS One. 2014;9(4):e94821. Published 2014 Apr 17.
[43]Novak M, Winkelman JW, Unruh M. Restless Legs Syndrome in Patients With Chronic Kidney Disease.?Semin Nephrol. 2015;35(4):347-358.
[44]Atalay H, Solak Y, Biyik Z, Gaipov A, Guney F, Turk S. Cross-over, open-label trial of the effects of gabapentin versus pregabalin on painful peripheral neuropathy and health-related quality of life in haemodialysis patients.?Clin Drug Investig. 2013;33(6):401-408.
[45]Lau T, Leung S, Lau W. Gabapentin for uremic pruritus in hemodialysis patients: a qualitative systematic review.?Can J Kidney Health Dis. 2016;3:14. Published 2016 Mar 28.
[46]Collister D, Pohl K, Herrington G, et al. The DIalysis Symptom COntrol-Restless Legs Syndrome (DISCO-RLS) Trial: A Protocol for a Randomized, Crossover, Placebo-Controlled Blinded Trial.?Can J Kidney Health Dis. 2020;7:2054358120968959. Published 2020 Nov 26.
[47]Feng WW, Yuan B, Shen FY, et al. Efficacy of uremic pruritus treatment in patients undergoing hemodialysis, a network meta-analysis for randomized clinical trials.?Nephrol Ther. 2021;17(1):30-34.
[48]Rhee EP, Guallar E, Hwang S, et al. Prevalence and Persistence of Uremic Symptoms in Incident Dialysis Patients.?Kidney360. 2020;1(2):86-92.
Outlines

/

[an error occurred while processing this directive]