Objective To investigate the incidence, severity and risk factors of pruritus in maintenance hemodialysis (MHD) patients. Methods The MHD patients in the nephrology departments of eleven hospitals were enrolled in this study. Patient self-reported pruritus was assessed by the Visual Analog Scale (VAS). The observed indicators included current dialysis scheme, dialysis age, complications, medications, and laboratory tests relating to calcium and phosphorus metabolism. Results A total of 1,540 patients were investigated, with 78.7% reporting pruritus, of which 34.2% had moderate to severe pruritus; the overall mean pruritus VAS score was 2.85±2.52. Lower Kt/V (β=-0.562, 95% CI:-0.916～-0.207, P=0.002), use of calcimimetics (β=-1.094, 95% CI: -1.462～-0.725, P＜0.001), HD+HDF protocol (β=0.604, 95% CI:0.119～1.089, P=0.015), HD+HDF+HP protocol (β=0.967, 95% CI:0.453～1.481, P＜0.001), hemodialysis combined with peritoneal dialysis (β=0.989, 95% CI:0.078～1.900, P=0.033), use of calcitriol (β=0.564, 95% CI:0.250～0.877, P＜0.001), use of topical antipruritics (β=2.740, 95% CI:2.052～3.428, P＜0.001), anemia (β=0.575, 95% CI:0.245～0.905, P＜0.001), chronic kidney disease-mineral and bone disease (β=0.841, 95% CI:0.527～1.155, P＜0.001), and higher calcium-phosphorus product (β=1.898, 95% CI:0.645～3.152, P=0.003) were associated with higher risk of pruritus. Conclusion The higher prevalence of pruritus in MHD patients is mainly associated with the abnormalities of calcium and phosphorus metabolism.
BAO Hong-Da
,
WANG Xiao-Xia
,
ZHANG Li-Ming
,
WANG Ying-Deng
,
ZOU Jian-Zhou
,
FU Peng
,
MA Jun
,
LI Jiang-Tao
,
WANG Feng
,
ZHANG Ran
,
WANG Nian-Song
,
JIANG Geng-Ru
. A multi-center clinical research on the occurrence and influencing factors of pruritus in maintenance hemodialysis patients[J]. Chinese Journal of Blood Purification, 2022
, 21(11)
: 813
-817,839
.
DOI: 10.3969/j.issn.1671-4091.2022.11.006
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