Novel factors involved in chronic kidney disease-mineral and bone disorder (CKD-MBD)&nbsp;

GUO Xin; FANG Jing-Ai; WANG Rui-Hua; ZHANG Xiao-Dong; LIU Wen-Yuan; CHANG Qin-Tao

doi:10.3969/j.issn.1671-4091.2023.01.010

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Chinese Journal of Blood Purification >

2023 , Vol. 22 >Issue 1: 44 - 47

DOI: https://doi.org/10.3969/j.issn.1671-4091.2023.01.010

Novel factors involved in chronic kidney disease-mineral and bone disorder (CKD-MBD)

GUO Xin ,
FANG Jing-Ai ,
WANG Rui-Hua ,
ZHANG Xiao-Dong ,
LIU Wen-Yuan ,
CHANG Qin-Tao

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First Clinical College, Shanxi Medical University, Taiyuan 030001,China; 2Department of Nephrology, the First Hospital of Shanxi Medical University, Taiyuan 030001, China

Received date: 2022-06-06

Revised date: 2022-08-12

Online published: 2023-01-12

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Abstract

Many biological factors are involved in the occurrence and development of chronic kidney disease-mineral and bone disorder (CKD-MBD). In addition to the classic parathyroid hormone (PTH)/vitamin D axis theory, recent studies have found that fibroblast growth factor 23, FGF23/Klotho, dentin matrix protein 1 (DMP1), secretory protein DicKKOPF-1 (DKK1) and sclerostin are also directly or indirectly involved in the progression of CKD-MBD. This paper reviews the latest research on these factors.

Key words： Chronic kidney disease-mineral and bone disorder; ; Fibroblast growth factor 23/Klotho; DKK1; Sclerostin; Dentin matrix protein1

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GUO Xin , FANG Jing-Ai , WANG Rui-Hua , ZHANG Xiao-Dong , LIU Wen-Yuan , CHANG Qin-Tao . Novel factors involved in chronic kidney disease-mineral and bone disorder (CKD-MBD) [J]. Chinese Journal of Blood Purification, 2023 , 22(1) : 44 -47 . DOI: 10.3969/j.issn.1671-4091.2023.01.010

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