Objective To explore the levels of serum glucose regulatory protein 78 (GRP78) and bone morphogenetic protein 2 (BMP2) in patients with maintenance hemodialysis (MHD) and their correlation with vascular calcification (VC). Methods During April 2020 to May 2022, 112 patients with MHD admitted to Sanhe Yanjiao Fuhe first hospital were selected as the study objects. Clinical data were collected, serum GRP78 and BMP2 levels were detected, and the incidence of VC was counted; the correlation between serum GRP78 and BMP2 levels in MHD patients, serum GRP78 and BMP2 levels in VC patients and general clinical data were analyzed, and the risk factors of VC in MHD patients. Results Among the 112 patients included, 52 had mild to moderate calcification (mild and moderate calcification group), 21 patients had severe calcification (severe calcification group), 39 patients did not develop VC (non-calcification group); There were significantly differences in age, proportion of diabetes, albumin (Alb), hemoglobin (Hb), blood phosphorus, serum calcium, calcium phosphorus product, intact parathyroid hormone (iPTH), serum GRP78, BMP2 levels among the non-calcification group, mild and moderate calcification group, severe calcification group (F/c2=38.987, 20.187, 34.952, 43.411, 34.541, 11.572, 48.522, 598.639, 123.029, 259.490, all P<0.001); there was a positive correlation between serum GRP78 and BMP2 in MHD patients (r=0.490, P<0.001); the level of serum GRP78 in VC patients was positively correlated with age, diabetes, blood phosphorus, blood calcium, calcium phosphorus product and iPTH (r=0.581, 0.339, 0.516, 0.534, 0.611, 0.513, all P<0.001), and negatively correlated with Alb and Hb (r=-0.302, -0.296, P=0.005, 0.007); the level of serum BMP2 in VC patients was positively correlated with age, diabetes, blood phosphorus, blood calcium, calcium phosphorus product and iPTH (r=0.524, 0.415, 0.535, 0.547, 0.602, 0.498, all P<0.001), and negatively correlated with Alb and Hb (r=-0.298, -0.284, P=0.008, 0.011); age, calcium phosphorus product, iPTH, GRP78 and BMP2 were the risk factors of VC in MHD patients (OR values are 3.009, 4.321, 4.719, 6.679, 6.237 respectively; 95% CI were 1.337～6.774, 1.634～11.423, 1.693～13.153, 1.951～22.871, 1.962～19.824 respectively; P values were 0.008, 0.003, 0.003, 0.002, 0.002 respectively). Conclusion The serum levels of GRP78 and BMP2 in MHD patients are related to the occurrence and condition of VC, the elevated levels of GRP78 and BMP2 are risk factors for the occurrence of VC.
【Key words】 Maintenance hemodialysis; Glucose regulatory protein 78; Bone morphogenetic protein 2; Vascular calcification
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