[an error occurred while processing this directive]

The role of sympathetic nerve activation in neointimal hyperplasia of autogenous arteriovenous fistula  

  • WANG Qun ,
  • LIANG Li-Ming ,
  • KONG Xiang-Lei
Expand
  • Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China; 2Department of Nephrology, Shandong Provincial Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Jinan 250014, China; 3Nephrology Research Institute of Shandong Province, Jinan 250014, China

Received date: 2022-12-06

  Revised date: 2023-01-14

  Online published: 2023-06-12

Supported by

国家自然科学基金青年基金(82000728);中国初级卫生保健基金会面上项目(HT202112220001);齐鲁卫生与健康杰出青年人才项目(A001358)

Abstract

Autologous arteriovenous fistula (AVF) is the most important route of blood access for hemodialysis, and failure of AVF may seriously limit its clinical application. Stenosis in venous outflow tract is a common cause of AVF failure, pathologically due to the neointimal hyperplasia (NIH). The mechanisms underlying NIH include a series of cascade reactions in local vessels, such as inflammation, oxidative stress and vascular remodeling, leading to vascular stenosis and AVF failure. On the other hand, hyperactive sympathetic nerve function is frequently present in end stage renal disease patients, which may also take part in the occurrence of NIH and AVF dysfunction through several pathways. This review focuses on the possible mechanisms of sympathetic activation to the development of NIH, aiming to provide a new theoretical explanation and a new intervention target for the prevention and treatment of AVF failure.

Cite this article

WANG Qun , LIANG Li-Ming , KONG Xiang-Lei . The role of sympathetic nerve activation in neointimal hyperplasia of autogenous arteriovenous fistula  [J]. Chinese Journal of Blood Purification, 2023 , 22(06) : 442 -445 . DOI: 10.3969/j.issn.1671-4091.2023.06.009

References

[1]ZHANG L, WANG F, WANG L, et al.Prevalence of chronic kidney disease in China: a cross-sectional survey[J].Lancet, 2012, 379(9818):815-22 [2]ZHANG L, LONG J, JIANG W, et al.Trends in Chronic Kidney Disease in China[J].N Engl J Med, 2016, 375(9):905-6 [3]KONG X, TANG L, LIANG L, et al.Clinical outcomes following the surgery of new autologous arteriovenous fistulas proximal to the failed ones in end-stage renal disease patients: a retrospective cohort study[J].Ren Fail, 2019, 41(1):1036-44 [4]DU J, LIANG L, LIU S, et al.Neointimal hyperplasia in the inferior vena cava of adenine-induced chronic kidney disease rats with aortocaval fistulas[J].Clin Exp Nephrol, 2020, 24(11):1007-14 [5]GRASSI G, BIFFI A, SERAVALLE G, et al.Sympathetic nerve traffic overactivity in chronic kidney disease: a systematic review and meta-analysis[J].J Hypertens, 2021, 39(3):408-16 [6]OSBORN J W, FOSS J D.Renal Nerves and Long-Term Control of Arterial Pressure[J].Compr Physiol, 2017, 7(2):263-320 [7]CONVERSE R L, JR.JACOBSEN T N,TOTO R D,et alSympathetic overactivity in patients with chronic renal failure[J].N Engl J Med, 1992, 327(27):1912-8 [8]TANAKA S, OKUSA M D.Crosstalk between the nervous system and the kidney[J].Kidney International, 2020, 97(3):466-76 [9]SATA Y, HEAD G A, DENTON K, et al.Role of the Sympathetic Nervous System and Its Modulation in Renal Hypertension. [J].Front Med (Lausanne), 2018, 5(/):82-/ [10]HAJARALSADAT HOSSEINI-DASTGERDI F K, ALI-ASGHAR POURSHANAZARI, AND MEHDI NEMATBAKHSH.Renal Denervation Influences Angiotensin II Types 1 and 2 Receptors.[J].International Journal of Nephrology, 2022, 2022(/):11-/ [11]SATA Y, BURKE S L, WATSON A M D, et al.Differential sympathetic response to lesion-induced chronic kidney disease in rabbits[J].Kidney Int, 2020, 98(4):906-17 [12]ALPERS C E, IMREY P B, HUDKINS K L, et al.Histopathology of Veins Obtained at Hemodialysis Arteriovenous Fistula Creation Surgery[J].Journal of the American Society of Nephrology, 2017, 28(10):3076-88 [13]WOODSIDE K J, BELL S, MUKHOPADHYAY P, et al.Arteriovenous Fistula Maturation in Prevalent Hemodialysis Patients in the United States: A National Study[J].Am J Kidney Dis, 2018, 71(6):793-801 [14]孔祥雷, 韩雯雯, 苏红.内皮细胞成分在尿毒症患者及健康人血清中的差异表达[J].国际泌尿系统杂志, 2017, 37(04):563-6 [15]KONG X, DU J, SU H, et al.Serum levels of the endothelial glycocalyx constituents and the early failure of forearm autologous arteriovenous fistulas in end-stage renal disease patients: a prospective cohort study[J].Int Urol Nephrol, 2020, 52(1):169-77 [16]BUBB K J, DRUMMOND G R, FIGTREE G A.New opportunities for targeting redox dysregulation in cardiovascular disease[J].Cardiovasc Res, 2020, 116(3):532-44 [17]FORSTERMANN U, XIA N, LI H.Roles of Vascular Oxidative Stress and Nitric Oxide in the Pathogenesis of Atherosclerosis[J].Circ Res, 2017, 120(4):713-35 [18]SHIU Y T, ROTMANS J I, GEELHOED W J, et al.Arteriovenous conduits for hemodialysis: how to better modulate the pathophysiological vascular response to optimize vascular access durability[J].Am J Physiol Renal Physiol, 2019, 316(5):F794-F806 [19]NGUYEN M, THANKAM F G, AGRAWAL D K.Sterile inflammation in the pathogenesis of maturation failure of arteriovenous fistula[J].J Mol Med (Berl), 2021, 99(6):729-41 [20]JUNCOS J P, GRANDE J P, KANG L, et al.MCP-1 contributes to arteriovenous fistula failure[J].J Am Soc Nephrol, 2011, 22(1):43-8 [21]MARTINEZ L, DUQUE J C, TABBARA M, et al.Fibrotic Venous Remodeling and Nonmaturation of Arteriovenous Fistulas[J].J Am Soc Nephrol, 2018, 29(3):1030-40 [22]FARIA M, DE PINHO M N.Challenges of reducing protein-bound uremic toxin levels in chronic kidney disease and end stage renal disease.[J].Transl Res, 2021, 229(/):115-34 [23]LAMBIE M, BONOMINI M, DAVIES S J, et al.Insulin resistance in cardiovascular disease,uremia,and peritoneal dialysis[J].Trends Endocrinol Metab, 2021, 32(9):721-30 [24]BRAHMBHATT A, REMUZZI A, FRANZONI M, et al.The molecular mechanisms of hemodialysis vascular access failure[J].Kidney Int, 2016, 89(2):303-16 [25]KAUR J, YOUNG B E, FADEL P J.Sympathetic Overactivity in Chronic Kidney Disease: Consequences and Mechanisms. [J].Int J Mol Sci, 2017, 18(8):/-/ [26]CAO W, WU L, ZHANG X, et al.Sympathetic Overactivity in CKD Disrupts Buffering of Neurotransmission by Endothelium-Derived Hyperpolarizing Factor and Enhances Vasoconstriction[J].J Am Soc Nephrol, 2020, 31(10):2312-25 [27]FONKOUE I T, MARVAR P J, NORRHOLM S, et al.Symptom severity impacts sympathetic dysregulation and inflammation in post-traumatic stress disorder. [J].Brain Behav Immun, 2020, 83(/):260-9 [28]CHEN H, WANG R, XU F, et al.Renal denervation mitigates atherosclerosis in ApoE-- mice via the suppression of inflammation[J].Am J Transl Res, 2020, 12(9):5362-80 [29]LI Z, LI Q, WANG L, et al.Targeting mitochondria-inflammation circle by renal denervation reduces atheroprone endothelial phenotypes and atherosclerosis.[J].Redox Biol, 2021, 47(/):102156-/ [30]SADAGHIANLOO N, CONTENTI J, DARDIK A, et al.Role of Hypoxia and Metabolism in the Development of Neointimal Hyperplasia in Arteriovenous Fistulas. [J].Int J Mol Sci, 2019, 20(21):/-/ [31]POLHEMUS D J, GAO J, SCARBOROUGH A L, et al.Radiofrequency Renal Denervation Protects the Ischemic Heart via Inhibition of GRK2 and Increased Nitric Oxide Signaling[J].Circ Res, 2016, 119(3):470-80 [32]SHARP T E, 3RD, LEFER D J.Renal Denervation to Treat Heart Failure. [J].Annu Rev Physiol, 2021, 83(/):39-58 [33]REY J, TOWNSEND R R.Renal Denervation: A Review[J].Am J Kidney Dis, 2022, 80(4):527-35 [34]UNDERWOOD C F, HILDRETH C M, WYSE B F, et al.Uraemia: an unrecognized driver of central neurohumoral dysfunction in chronic kidney disease?[J].Acta Physiol (Oxf), 2017, 219(1):305-23 [35]JANG H S, KIM J, PADANILAM B J.Renal sympathetic nerve activation via alpha2-adrenergic receptors in chronic kidney disease progression[J].Kidney Res Clin Pract, 2019, 38(1):6-14 [36]OSBORN J W, TYSHYNSKY R, VULCHANOVA L.Function of Renal Nerves in Kidney Physiology and Pathophysiology. [J].Annu Rev Physiol, 2021, 83(/):429-50 [37]LI Q, DENG Y, LIU L, et al.Sympathetic Denervation Ameliorates Renal Fibrosis via Inhibition of Cellular Senescence.[J].Front Immunol, 2021, 12(/):823935-/ [38]KIUCHI M G, ESLER M D, FINK G D, et al.Renal Denervation Update From the International Sympathetic Nervous System Summit: JACC State-of-the-Art Review[J].J Am Coll Cardiol, 2019, 73(23):3006-17 [39]CHEN T K, KNICELY D H, GRAMS M E.Chronic Kidney Disease Diagnosis and Management: A Review[J].JAMA, 2019, 322(13):1294-304 [40]BOHM M, KARIO K, KANDZARI D E, et al.Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre,randomised,sham-controlled trial[J].Lancet, 2020, 395(10234):1444-51 [41]SINGH R R, MCARDLE Z M, IUDICA M, et al.Sustained Decrease in Blood Pressure and Reduced Anatomical and Functional Reinnervation of Renal Nerves in Hypertensive Sheep 30 Months After Catheter-Based Renal Denervation[J].Hypertension, 2019, 73(3):718-27 [42]MAHFOUD F, MANCIA G, SCHMIEDER R, et al.Renal Denervation in High-Risk Patients With Hypertension[J].J Am Coll Cardiol, 2020, 75(23):2879-88 [43]MATHEW R O, BANGALORE S, LAVELLE M P, et al.Diagnosis and management of atherosclerotic cardiovascular disease in chronic kidney disease: a review[J].Kidney Int, 2017, 91(4):797-807 [44]TANAKA S, OKUSA M D.Crosstalk between the nervous system and the kidney[J].Kidney Int, 2020, 97(3):466-76 [45]MOHANTA S K, PENG L, LI Y, et al.Neuroimmune cardiovascular interfaces control atherosclerosis[J].Nature, 2022, 605(7908):152-9 [46]CAPLICE N M, WANG S, TRACZ M, et al.Neoangiogenesis and the presence of progenitor cells in the venous limb of an arteriovenous fistula in the rat[J].Am J Physiol Renal Physiol, 2007, 293(2):F470-5
Outlines

/

[an error occurred while processing this directive]