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Advances in the study of bone markers for vascular calcification in chronic renal failure patients 

  • LIAO Sheng-Chun ,
  • YE Chao-Yang
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  • Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Institute of Traditional Chinese Medicine Kidney Disease, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

Received date: 2023-05-23

  Revised date: 2023-06-05

  Online published: 2023-08-12

Abstract

Vascular calcification (VC) caused by chronic kidney disease-mineral and bone disorder (CKD-MBD) is an important clinical complication, and contributes to the higher cardiovascular mortality in CKD patients. Bone markers can be detected or even involved in the process of VC. Bone markers play important roles in the study of VC. In this paper, we provide an in-depth study of the mechanism of VC, and review the mutual feedback effects among common bone markers such as parathyroid hormone, 25-hydroxyvitamin D, fibroblast growth factor 23 and Klotho (PTH-25OHVitD-FGF23-Klotho). We also summarize the recent research progresses in osteocalcin (OCN), type I collagen carboxy-terminal peptide β special sequence (β-CTX), and total type I collagen amino-terminal extension peptide (tP1NP).

Cite this article

LIAO Sheng-Chun , YE Chao-Yang . Advances in the study of bone markers for vascular calcification in chronic renal failure patients [J]. Chinese Journal of Blood Purification, 2023 , 22(08) : 608 -611 . DOI: 10.3969/j.issn.1671-4091.2023.08.009

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