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Research progresses in mesenchymal stem cells to delay peritoneal fibrosis

  • ZHANG Qing-Ru ,
  • LIU Xiao-Yu ,
  • LU Xue-Hong
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  • Department of Nephrology, The Second Hospital, Jilin University, Changchun 130041, China

Received date: 2023-04-07

  Revised date: 2023-07-01

  Online published: 2023-09-12

Abstract

Peritoneal dialysis (PD) is one of the kidney replacement treatments and plays an irreplaceable role in the treatment of end-stage renal failure patients. However, long-term PD can affect the function and structure of the peritoneum. Peritoneal fibrosis is a serious complication in long-term PD patients, leading to ultrafiltration failure and interruption of PD. In recent years, mesenchymal stem cells (MSCs) have become an innovative research field with clinical application potential due to their multi-directional differentiation potential, immunomodulatory and tissue repair abilities. Recent studies have shown that MSCs can ameliorate peritoneal fibrosis by regulating inflammation, repairing damage, and inhibiting epithelial-mesenchymal transformation (EMT) of the peritoneal mesenchymal cells. This article reviews the mechanism, research progresses and difficulties of MSCs used for delaying peritoneal fibrosis.

Cite this article

ZHANG Qing-Ru , LIU Xiao-Yu , LU Xue-Hong . Research progresses in mesenchymal stem cells to delay peritoneal fibrosis[J]. Chinese Journal of Blood Purification, 2023 , 22(09) : 690 -694 . DOI: 10.3969/j.issn.1671-4091.2023.09.012

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