Objective  To investigate the effects of hemodialysis (HD) combined with hemoperfusion (HP) on blood lipids and micro inflammatory status in uremic patients.  Method  A total of 60 uremic patients undergoing maintenance hemodialysis at the Blood Purification Center of the Northern Theater Command General Hospital from December 2018 to December 2020 were recruited for this study. They were divided using a random number table method into a control group and an experiment group with 30 cases in each group. The patients in the control group received routine hemodialysis, while the patients in the experiment group received hemoperfusion in addition to hemodialysis in the control group. Before treatment and 12 weeks after the treatment, blood samples were collected to observe the changes of total cholesterol (TC), triacylglycerol (TG), high-density lipoprotein (HDL-C), low density lipoprotein cholesterol (LDL-C), C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor α (TNF-α).  Result  There were no statistical differences in the levels of TC, TG, HDL-C and LDL-C before treatment between the two groups (t=1.582, 0.488, 0.096 and 0.908 respectively; P=0.119, 0.627, 0.924 and 0.368 respectively). After 12 weeks of treatment, the levels of TC, TG and LDL-C were lower in the experiment group than in the control group (t=2.101, 4.308 and 2.521 respectively; P=0.040, <0.001 and 0.014 respectively), while serum HDL-C was higher in the experiment group than in the control group (t=3.408, P=0.001); the improvement of TC, TG, HDL-C and LDL-C levels were better in the experiment group than in the control group (t=3.709, 2.108, 2.336 and 3.401 respectively; P<0.001, 0.039, 0.023 and 0.001 respectively); CRP, IL-6 and TNF-α decreased in both groups (t=3.062, 2.694 and 4.575 respectively; P=0.003, 0.009 and <0.001 respectively), but the levels of improvement were better in the experiment group than in the control group (t=8.574, 7.698 and 9.256 respectively; P<0.001).  Conclusion  The combination of hemodialysis and hemoperfusion can effectively improve the blood lipid metabolism, the clearance of inflammatory factors and the micro inflammatory state in maintenance hemodialysis patients. This method is worthwhile to be widely used clinically.