[an error occurred while processing this directive]

Research progresses in the intraoperative parathyroid hormone determination during the operation for secondary hyperparathyroidism

  • LIAN Li-Xin ,
  • GAO Wen-Chao ,
  • LI Tong-Chang ,
  • LI Tong-Chang Wen-Chao ,
  • LI Xiao-Yang ,
  • QI Ming
Expand
  • The Fourth General Surgery Department, The First Hospital of Harbin, Harbin 150000, China

Received date: 2023-09-28

  Revised date: 2023-11-04

  Online published: 2024-01-12

Abstract

Parathyroidectomy can effectively treat the secondary hyperparathyroidism (SHPT). However, complete resection of the parathyroid glands during operation is often impossible due to the anatomical and physiological characteristics of parathyroid glands. Thereby the risk of short-term or long-term recurrence increases. Intraoperative parathyroid hormone (ioPTH) determination has been proven to be of great value in improving effectiveness and safety of the surgery and in reducing the recurrence and complications after the surgery. However, there is no consensus on determination standard. This paper aims to review the research progresses and current status of ioPTH during parathyroidectomy surgery for SHPT and to provide more theoretical bases and research targets for SHPT surgery.

Cite this article

LIAN Li-Xin , GAO Wen-Chao , LI Tong-Chang , LI Tong-Chang Wen-Chao , LI Xiao-Yang , QI Ming . Research progresses in the intraoperative parathyroid hormone determination during the operation for secondary hyperparathyroidism[J]. Chinese Journal of Blood Purification, 2024 , 23(01) : 50 -52 . DOI: 10.3969/j.issn.1671-4091.2024.01.011

References

[1]Ivarsson KM, Akaberi S, Isaksson E, et al.The effect of parathyroidectomy on patient survival in secondary hyperparathyroidism[J].Nephrol Dial Transplant, 2015, 30(12):2027-2033 [2]Malberti F, Marcelli D, Conte F, et al.Parathyroidectomy in patients on renal replacement therapy: an epidemiologic study[J].J Am Soc Nephrol, 2001, 12(6):1242-1248 [3]Packman KS, Demeure MJ.Indications for parathyroidectomy and extent of treatment for patients with secondary hyperparathyroidism[J].Surg Clin North Am, 1995, 75(3):465-482 [4]Conzo G, Perna AF, Sinisi AA, et al.Total parathyroidectomy without autotransplantation in the surgical treatment of secondary hyperparathyroidism of chronic kidney disease[J].J Endocrinol Invest, 2012, 35(1):8-13 [5]Stracke S, Keller F, Steinbach G, et al.Long-term outcome after total parathyroidectomy for the management of secondary hyperparathyroidism[J].Nephron Clin Pract, 2009, 111(2):102-109 [6]Moor JW, Roberts S, Atkin SL, et al.Intraoperative parathyroid hormone monitoring to determine long-term success of total parathyroidectomy for secondary hyperparathyroidism[J].Head Neck, 2011, 33(3):293-296 [7]Datta NS, Abou-Samra AB.PTH and PTHrP signaling in osteoblasts[J].Cell Signal, 2009, 21(8):1245-1254 [8]Shiotani A, Takami M, Itoh K, et al.Regulation of osteoclast differentiation and function by receptor activator of NFkB ligand and osteoprotegerin[J].Anat Rec, 2002, 268(2):137-146 [9]Brossard JH, Cloutier M, Roy L, et al.Accumulation of a non-(1-84) molecular form of parathyroid hormone (PTH) detected by intact PTH assay in renal failure: importance in the interpretation of PTH values[J].J Clin Endocrinol Metab, 1996, 81(11):3923-3929 [10]Pitt SC, Panneerselvan R, Chen H, et al.Secondary and tertiary hyperparathyroidism: the utility of ioPTH monitoring[J].World J Surg, 2010, 34(6):1343-1349 [11]Chávez KV, Márquez-González H, Chavez-Tostado M.The Usefulness of Intraoperative PTH as a Predictor for Successful Parathyroidectomy in Secondary Hyperparathyroidism[J]. Front Surg, 2021, 8: 696469.[J].Front Surg, 2021, 8(-):696469-696469 [12]Roche AM, Brant JA, Chai RL.Predictors of Readmission and Reoperation in Patients Undergoing Parathyroidectomy for Primary Hyperparathyroidism[J].Otolaryngol Head Neck Surg, 2018, 158(5):828-834 [13]Irvin GL 3rd, Dembrow VD, Prudhomme DL.Operative monitoring of parathyroid gland hyperfunction[J].Am J Surg, 1991, 162(4):299-302 [14]Lorenz K, Bartsch DK, Sancho JJ, et al.Surgical management of secondary hyperparathyroidism in chronic kidney disease--a consensus report of the European Society of Endocrine Surgeons[J].Langenbecks Arch Surg, 2015, 400(8):907-27 [15]Barczyński M, Cichoń S, Konturek A, et al.A randomised study on a new cost-effective algorithm of quick intraoperative intact parathyroid hormone assay in secondary hyperparathyroidism[J].Langenbecks Arch Surg, 2005, 390(2):121-127 [16]Freriks K, Hermus AR, de Sévaux RG, et al.Usefulness of intraoperative parathyroid hormone measurements in patients with renal hyperparathyroidism[J].Head Neck, 2010, 32(10):1328-1335 [17]Van Beek DJ, Fredriksson S, Haegele S, et al.Use of intraoperative parathyroid hormone measurements during parathyroidectomy to predict postoperative parathyroid hormone levels in patients with renal hyperparathyroidism: meta-analysis[J].BJS Open, 2022, 6(1):zrab151-zrab151 [18]Konturek A, Barczyński M, Stopa M, et al.Subtotal parathyroidectomy for secondary renal hyperparathyroidism: a 20-year surgical outcome study[J].Langenbecks Arch Surg, 2016, 401(7):965-974 [19]Ohe MN, Santos RO, Kunii IS, et al.Usefulness of a rapid immunometric assay for intraoperative parathyroid hormone measurements[J].Braz J Med Biol Res, 2003, 36(6):715-721 [20]Proye CA, Goropoulos A, Franz C, et al.Usefulness and limits of quick intraoperative measurements of intact (1-84) parathyroid hormone in the surgical management of hyperparathyroidism: sequential measurements in patients with multiglandular disease[J].Surgery, 1991, 110(6):1035-1042
Outlines

/

[an error occurred while processing this directive]