Objective  To explore the influence of drug informatization management based on the collaboration between doctors and nurses on the compliance with dialysis medications and biochemistry parameters in hemodialysis outpatients.  Methods  A total of 252 hemodialysis outpatients treated in the Blood Purification Division, Cangzhou Central Hospital from October 2021 to September 2022 were recruited using the convenience sampling method. The routine drug management method was used during October 2021 to March 2022, and the informatization management for dialysis medications based on the collaboration between doctors and nurses was used during April 2022 to September 2022. Paired t-test and paired χ2 test were used to compare the compliance with dialysis medications and biochemical parameters before and after the drug informatization management in hemodialysis patients.  Results  The compliance score of dialysis medications (t=32.563, P<0.001), hemoglobin (χ2=11.021, P=0.001), albumin (χ2=8.481, P=0.004), serum calcium (χ2=24.735, P<0.001), and intact parathyroid hormone (χ2=11.529, P=0.001) improved significantly after drug infomatization management, as compared those before drug infomatization management.  Conclusion  Drug informatization management based on the collaboration between doctors and nurses improves the compliance with dialysis medications and biochemical parameters in hemodialysis patients. This method is worthwhile to be used clinically.