Research advances in the relationship between hypoxia-inducible factor-1α and renal fibrosis

YAN Tong; JIA Xin-Yan; GUO Ming-Hao

doi:10.3969/j.issn.1671-4091.2024.02.011

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Chinese Journal of Blood Purification >

2024 , Vol. 23 >Issue 02: 130 - 133

DOI: https://doi.org/10.3969/j.issn.1671-4091.2024.02.011

Research advances in the relationship between hypoxia-inducible factor-1α and renal fibrosis

YAN Tong ,
JIA Xin-Yan ,
GUO Ming-Hao

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Department of Nephrology, The First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China

Received date: 2023-10-23

Revised date: 2023-11-28

Online published: 2024-02-12

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Abstract

Renal fibrosis is the common pathological hallmark of various chronic kidney diseases, characterized by progressive accumulation of extracellular matrix (ECM). Hypoxia-inducible factor (HIF) is a key regulator of body’s response to hypoxia. HIF regulates ECM synthesis, epithelial-mesenchymal transition (EMT) and pro-fibrosis signaling pathways. This review summarized the relationship between HIF-1α and renal fibrosis.

Key words： Hypoxia; Hypoxia-inducible factor; Renal fibrosis; Epithelial-mesenchymal transition

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YAN Tong , JIA Xin-Yan , GUO Ming-Hao . Research advances in the relationship between hypoxia-inducible factor-1α and renal fibrosis[J]. Chinese Journal of Blood Purification, 2024 , 23(02) : 130 -133 . DOI: 10.3969/j.issn.1671-4091.2024.02.011

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