[an error occurred while processing this directive]

Evidence of benefits and achievement of high-volume hemodiafiltration

  • DU Hui ,
  • ZUO Li
Expand
  • Global Medical Office, Fresenius Medical Care, Beijing 100028, China; 2Department of Nephrology, Peking University People’s Hospital, Beijing 100044, China

Received date: 2023-12-28

  Revised date: 2024-01-19

  Online published: 2024-04-12

Abstract

Hemodiafiltration(HDF)works by combining diffusive and convective solute removal to provide a greater removal of larger molecular weight uremic toxins. The recent publication of the CONVINCE study might be a milestone in ending the controversy over whether this treatment modality can provide long-term survival benefits for patients with end-stage renal disease(ESRD)requiring renal replacement therapy. This review gives a brief overview of the current evidence for the clinical benefits of HDF as well as the important factors and stepwise protocols for high-volume HDF achievements.

Cite this article

DU Hui , ZUO Li . Evidence of benefits and achievement of high-volume hemodiafiltration[J]. Chinese Journal of Blood Purification, 2024 , 23(04) : 241 -244,289 . DOI: 10.3969/j.issn.1671-4091.2024.04.001

References

1. Leber, H.;Wizemann, V.; Goubeaud, G.; Rawer, P.; Schütterle, G. Hemodiafiltration: A New Alternative to Hemofiltration and Conventional Hemodialysis. Artif. Organs 1978, 2, 150–153.
2. Ingrid Ledebo. On-line preparation of solutions for dialysis: practical aspects versus safety and regulations. J Am Soc Nephrol 2002 Jan:13 Suppl 1:S78-83.
3. Canaud, B.; Bragg-Gresham, J.L.; Marshall, M.R.; Desmeules, S.; Gillespie, B.W.; Depner, T.; Klassen, P.; Port, F.K. Mortality Risk for Patients Receiving Hemodiafiltration versus Hemodialysis: European Results from the DOPPS. Kidney Int. 2006, 69, 2087–2093.
4. Grooteman, M.P.C.; van den Dorpel, M.A.; Bots, M.L.; Penne, E.L.; van der Weerd, N.C.; Mazairac, A.H.A.; den Hoedt, C.H.; van der Tweel, I.; Lévesque, R.; Nubé, M.J.; et al. Effect of Online Hemodiafiltration on All-Cause Mortality and Cardiovascular Outcomes. J. Am. Soc. Nephrol. 2012, 23, 1087–1096.
5. Maduell, F.; Moreso, F.; Pons, M.; Ramos, R.; Mora-Macià, J.; Carreras, J.; Soler, J.; Torres, F.; Campistol, J.M.; Martinez-Castelao, A.; et al. High-Efficiency Postdilution Online Hemodiafiltration Reduces All-Cause Mortality in Hemodialysis Patients. J. Am. Soc. Nephrol. 2013, 24, 487–497.
6. Ok, E.; Asci, G.; Toz, H.; Ok, E.S.; Kircelli, F.; Yilmaz, M.; Hur, E.; Demirci, M.S.; Demirci, C.; Duman, S.; et al. Mortality and Cardiovascular Events in Online Haemodiafiltration (OL-HDF) Compared with High-Flux Dialysis: Results from the Turkish OL-HDF Study. Nephrol. Dial. Transplant. 2013, 28, 192–202.
7. Morena, M.; Jaussent, A.; Chalabi, L.; Leray-Moragues, H.; Chenine, L.; Debure, A.; Thibaudin, D.; Azzouz, L.; Patrier, L.; Maurice, F.; et al. Treatment Tolerance and Patient-Reported Outcomes Favor Online Hemodiafiltration Compared to High-Flux Hemodialysis in the Elderly. Kidney Int. 2017, 91, 1495–1509.
8. Peters, S.A.E.; Bots, M.L.; Canaud, B.; Davenport, A.; Grooteman, M.P.C.; Kircelli, F.; Locatelli, F.; Maduell, F.; Morena, M.; Nubé, M.J.; et al. Haemodiafiltration and Mortality in End-Stage Kidney Disease Patients: A Pooled Individual Participant Data Analysis from Four Randomized Controlled Trials. Nephrol. Dial. Transplant. 2016, 31, 978–984.
9. Lucile Mercadal, Jeanna-Eve Franck, Marie Metzger, Pablo Urena Torres, Fran?ois de Cornelissen, Stéphane Edet, Clémence Béchade, Cécile Vigneau, Tilman Drüeke, Christian Jacquelinet, Bénédicte Stengel; REIN Registry. Hemodiafiltration Versus Hemodialysis and Survival in Patients With ESRD: The French Renal Epidemiology and Information Network (REIN) Registry. Am J Kidney Dis . 2016 Aug;68(2):247-255.
10. Emily J See, James Hedley, John W M Agar, Carmel M Hawley, David W Johnson, Patrick J Kelly, Vincent W Lee, Kathy Mac, Kevan R Polkinghorne, Kannaiyan S Rabindranath, Kamal Sud, Angela C Webster. Patient survival on haemodiafiltration and haemodialysis: a cohort study using the Australia and New Zealand Dialysis and Transplant Registry. Nephrol Dial Transplant . 2019 Feb 1;34(2):326-338.
11. Kan Kikuchi, Takayuki Hamano, Atsushi Wada, Shigeru Nakai, Ikuto Masakane. Predilution online hemodiafiltration is associated with improved survival compared with hemodialysis. Kidney Int . 2019 Apr;95(4):929-938.
12. Blankestijn, P.J.; Vernooij, R.W.M.; Hockham, C.; Strippoli, G.F.M.; Canaud, B.; Hegbrant, J.; Barth, C.; Covic, A.; Cromm, K.; Cucui, A.; et al. Effect of Hemodiafiltration or Hemodialysis on Mortality in Kidney Failure. N. Engl. J. Med. 2023.
13. Fergus J Caskey, Sunita Procter, Stephanie J MacNeill, Julia Wade, Jodi Taylor, Leila Rooshenas, Yumeng Liu, Ammar Annaw, Karen Alloway, Andrew Davenport, Albert Power, Ken Farrington, Sandip Mitra, David C Wheeler, Kristian Law, Helen Lewis-White, Yoav Ben-Shlomo, Will Hollingworth, Jenny Donovan, J Athene Lane. The high-volume haemodiafiltration vs high-flux haemodialysis registry trial (H4RT): a multi-centre, unblinded, randomised, parallel-group, superiority study to compare the effectiveness and cost-effectiveness of high-volume haemodiafiltration and high-flux haemodialysis in people with kidney failure on maintenance dialysis using linkage to routine healthcare databases for outcomes. Trials . 2022 Jun 27;23(1):532.
14. Shroff R, Basile C, van der Sande F, Mitra S; EuDial Working Group of the European Renal Association. Haemodiafiltration for all: are we CONVINCEd? 2023;38(12):2663-2665.
15. James E Tattersall 1, Richard A Ward; EUDIAL group. Online haemodiafiltration: definition, dose quantification and safety revisited. Nephrol Dial Transplant . 2013 Mar;28(3):542-50.
16. Daniele Marcelli , Caecilia Scholz, Pedro Ponce, Tania Sousa, Pascal Kopperschmidt, Aileen Grassmann, Bruno Pinto, Bernard Canaud. High-volume postdilution hemodiafiltration is a feasible option in routine clinical practice. Artif Organs. 2015 Feb;39(2):142-9. doi: 10.1111/aor.12345.
17. Isabelle Chapdelaine 1, Ira M Mostovaya, Peter J Blankestijn, Michiel L Bots, Marinus A van den Dorpel, Renée Lévesque, Menso J Nubé, Piet M ter Wee, Muriel P C Grooteman; CONTRAST investigators. Treatment policy rather than patient characteristics determines convection volume in online post-dilution hemodiafiltration. Blood Purif . 2014;37(3):229-37. doi: 10.1159/000362108.
18. Canaud B, Davenport A. Prescription of online hemodiafiltration (ol-HDF). Semin Dial. 2022 Sep;35(5):413-419. doi: 10.1111/sdi.13070.
19. Maduell F, Ojeda R, Belmar L, et al. Evaluation of the dialyser inner diameter in online haemodiafiltration. Nefrologia (Engl Ed). 2018;38(1): 34-40. doi:10.1016/j.nefroe.2017.11.015
20. Potier J, Queffeulou G, Bouet J. Are all dialyzers compatible with the convective volumes suggested for postdilution online hemodiafiltration? Int J Artif Organs. 2016;39(9):460-470. doi:10. 5301/ijao.5000525
21. Lang T, Zawada AM, Theis L, Braun J, Ottillinger B, Kopperschmidt P, Gagel A, Kotanko P, Stauss-Grabo M, Kennedy JP, Canaud B. Hemodiafiltration: Technical and Medical Insights. Bioengineering (Basel). 2023 Jan 21;10(2):145.
22. Blankestijn PJ, Fischer KI, Barth C, Cromm K, Canaud B, Davenport A, Grobbee DE, Hegbrant J, Roes KC, Rose M, Strippoli GF, Vernooij RW, Woodward M, de Wit GA de, Bots ML. Benefits and harms of high-dose haemodiafiltration versus high-flux haemodialysis: the comparison of high-dose haemodiafiltration with high-flux haemodialysis (CONVINCE) trial protocol. BMJ Open . 2020 Feb 5;10(2):e033228.
23. Isabelle Chapdelaine, Camiel L M de Roij van Zuijdewijn, Ira M Mostovaya, Renée Lévesque, Andrew Davenport, Peter J Blankestijn, Christoph Wanner, Menso J Nubé, Muriel P C Grooteman; EUDIAL Group; P J Blankestijn, A Davenport, C Basile, F Locatelli, F Maduell, S Mitra, C Ronco, R Shroff, J Tattersall, C Wanner. Optimization of the convection volume in online post-dilution haemodiafiltration: practical and technical issues. Clin Kidney J. 2015 Apr;8(2):191-8. doi: 10.1093/ckj/sfv003.
24. Guedes M, Dambiski AC, Canhada S, et al. Achieving high convective volume in hemodiafiltration: lessons learned after successful implementation in the HDFit trial. Hemodial Int. 2021;25(1):50-59. doi:10.1111/hdi.12891
25. Kim DH, Lee YK, Park HC, et al. Stepwise achievement of high convection volume in post-dilution hemodiafiltration: a prospective observational study. Semin Dial. 2021;34(5):368-374. doi:10.1111/sdi.12966
26. Daniele Marcelli, Pascal Kopperschmidt, Inga Bayh, Tomas Jirka, Jose I Merello, Pedro Ponce, Erzebeth Ladanyi, Attilio Di Benedetto, Reina Dovc-Dimec, Jaroslav Rosenberger, Stefano Stuard, Caecilia Scholz, Aileen Grassmann, Bernard Canaud. Modifiable factors associated with achievement of high-volume post-dilution hemodiafiltration: results from an international study. Int J Artif Organs . 2015 May;38(5):244-50. doi: 10.5301/ijao.5000414.
Outlines

/

[an error occurred while processing this directive]