Objective  To evaluate the effect of neutral pH and low glucose degradation products (glucose degradation products, GDPs) on CA125 in peritoneal dialysis (peritoneal dialysis,PD) patients. Methods Continuous ambulatory peritoneal dialysis  patients were enrolled. These patients were initially dialyzed with standard calcium peritoneal dialysis solution, followed by 6 months of dialysis with neutral pH and low GDPs peritoneal dialysis solution. Compare the concentrations of CA125 in the exudate and serum, ultrafiltration volume, and whether there is dialysis pain of these patients when using standard PD fluid (group A) and after using neutral pH and low GDPs PD fluid (group B).  Results  A total of 44 PD patients were included, including 24 males and 20 females. Compared with group A, group B had higher effluent CA125 (t=2.266, P=0.029), serum CA125 (t=2.575, P=0.014), peritoneal dialysis ultrafiltration (Z=5.052, P <0.001), and lower hemoglobin (t=2.208, P=0.033), calcium (t=2.843, P=0.007), and phosphorus (t=2.094, P=0.042).  Conclusion  The peritoneal dialysis fluid with neutral pH, low GDPs can increase the CA125 level in peritoneal dialysis patients, which indirectly indicates the reduced damage of peritoneal mesothelial cells.