Objective  To construct a core competency evaluation index system for nurses specializing in continuous renal replacement therapy (CRRT).  Methods   The first draft of core competence evaluation indexes for CRRT nurses was formulated by referring to domestic and international literature and after discussion in the research group. The second round of consultation with 16 experts was conducted from June to August 2023 by using the Delphi method, to complete the screening and modification of the indexes and to determine the weights of the indexes.   Results  The finalized core competency evaluation indicators for CRRT nurses included 7 first-level indicators (professional theoretical knowledge, professional practical ability, critical thinking ability, communication and coordination ability, management ability, professional development ability, and professional humanistic literacy ability), 27 second-level indicators, and 112 third-level indicators. The effective response rate of the two rounds of expert consultation was 100%, and the expert authority coefficient was 0.912. The Kendall harmony coefficients of the first-, second-, and third-level indicators of the second round of correspondence were 0.399, 0.278, and 0.208, respectively, and the results of the correspondence were all P<0.001.  Conclusion  The constructed core competency evaluation indexes for CRRT specialized nurses are scientific, rational, comprehensive, and professional. This evaluation index system can be used for the training and evaluation of CRRT specialized nurses.