Objective  To explore the research hotspot and development trend in home hemodialysis, and to provide references for the promotion and optimization of related research in China.  Methods  The literature related to home hemodialysis in the Web of Science core collection was searched, and CiteSpace 6.3 R1 software was used to visualized analyze the countries, institutions, authors, keywords, etc.  Results  A total of 315 articles were included in the English literature, involving 924 authors from 39 countries. In the past 10 years, home hemodialysis has shown a trend of fluctuation growth, mainly concentrated in developed countries such as Canada and United States. The research hotspots included patient safety, survival outcome, and barrier factors.  Conclusion  The research on home hemodialysis is currently in the processes of continuous exploration, improvement and maturation. For the promotion of home hemodialysis in China, a framework system must be established based on the demand of our dialysis patients and the advanced program of home hemodialysis in foreign countries.