Objective   To retrieve and summarize the best evidence for symptom management of restless leg syndrome (RLS) in maintenance hemodialysis (MHD) patients, and to provide evidence-based references for clinical practice.  Methods  Clinical decisions, guidelines, evidence summaries, systematic reviews, expert consensus and randomized controlled trials on RLS symptom management in MHD patients were systematically searched in domestic and foreign databases from establishment of the database to May 30, 2024.  Results  A total of 14 articles were picked up, including 4 clinical decisions, 2 guidelines, 1 evidence summary and 7 systematic reviews. A total of 29 titles of evidence were summarized in 8 aspects, including management benefit, diagnosis and management, risk/aggravating factors, evaluation and monitoring, dialysis optimization, supplementary replacement therapy, drug therapy and health education.  Conclusion  This study summarizes the best evidence for RLS symptom management in MHD patients, and provides evidence-based references for clinical practice in clinicians and nurses.