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Research progress in the use of indobufen and atorvastatin to prevent arteriovenous fistula failure

  • LUO Tong ,
  • YAN Yan
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  • Department of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China

Received date: 2024-11-08

  Revised date: 2024-12-26

  Online published: 2025-04-12

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Abstract

The outcome of continuous progression of chronic kidney disease (CKD) is the end-stage renal disease (ESRD). Hemodialysis (HD) is one of the main treatment options for ESRD patients. Arteriovenous fistula (AVF) is the preferred type of vascular access for maintenance HD patients. However, AVF dysfunction occurs frequently within 12 months after surgery. This article mainly focuses on the causes and mechanisms of AVF dysfunction, the treatment progress in improving AVF patency, the pharmacology of indobufen and atorvastatin and their effects on cerebral, cardiac and peripheral blood vessels and AVF patency; the preventive measures of vascular access dysfunction after AVF surgery, in particular the drug treatment after AVF surgery, are comprehensively studied, in order to prolong the lifespan of AVF in HD patients and to provide theoretic basis for maintaining vascular access. 

Cite this article

LUO Tong , YAN Yan . Research progress in the use of indobufen and atorvastatin to prevent arteriovenous fistula failure[J]. Chinese Journal of Blood Purification, 2025 , 24(04) : 304 -307 . DOI: 10.3969/j.issn.1671-4091.2025.04.010

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