Objective  To construct a palliative care intervention plan for patients with end-stage renal disease.  Method  A preliminary palliative care intervention plan for end-stage renal disease patients was developed through literature analysis. The final palliative care intervention plan was then established through Delphi expert consultation.  Result  The effective response rates of the two rounds of expert consultation questionnaires were 90.91% and 100.00%, respectively. The expert authority coefficients were 0.87 and 0.85, respectively. The final decision on the palliative care intervention plan for end-stage renal disease patients includes 3 primary indicators (pre dialysis, during dialysis, and post dialysis), 17 secondary indicators, and 81 tertiary indicators.  Conclusion  The palliative care intervention plan for end-stage renal disease patients developed in this study is scientific and reliable, and can provide reference and inspiration for the implementation of palliative care intervention measures for end-stage renal disease patients.