28 April 2026, Volume Issue 4
    

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  • Food and Nutrition in China. 2026, (4): 0-0.
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    Objective: To systematically evaluate the effects of oligosaccharides on the gastrointestinal health of infants and young children. Method: A comprehensive literature search was performed across multiple databases, including PubMed, Embase, Medline, Cochrane, China National Knowledge Infrastructure, Wanfang Database, and the China Biology Medicine database. The search utilized specific keywords such as ("Oligosaccharides" "Disaccharides" "Trisaccharides" "Cellobiose" "Isomaltose" "Lactose" "Lactulose" "Maltose" "Melibiose" "Sucrose" "Trehalose" "Acarbose" "Raffinose") ("Infant" "Infancy" "baby" "babies" "young child" "young children" "neonate" "neonates") ("Brain-Gut Axis" "Intestinal Diseases" "Intestinal Barrier Function" "Gastrointestinal Microbiome" "Inflammatory Bowel Diseases" "Intestinal tumors" "Probiotics" "Volatile Fatty Acids") The search covered relevant studies published from January 1, 2000, to September 25, 2024. Following the application of inclusion and exclusion criteria for study selection, the retrieved evidence was rigorously evaluated using the World Health Organization (WHO) recommended methodology and the GRADE system to ensure the quality and reliability of the findings. Result: A total of 27 studies were included, comprising 16 randomized controlled trials (RCTs), 5 non-randomized controlled studies, 4 cohort studies, 1 case-control study, and 1 single-arm trial. The results showed that 26 studies reported positive effects of oligosaccharides on infants' gastrointestinal health, including 21 studies indicating improvements in intestinal flora regulation, 2 RCTs and 2 non-randomized controlled studies showing improvements in defecation status, 4 RCTs revealing enhanced gut immunity and reduced infections, 2 RCTs reporting decreased gastrointestinal adverse reactions, and 2 RCTs highlighting the role of oligosaccharides in alleviating intestinal colic. The overall evidence suggested a beneficial impact of oligosaccharides on infants' gastrointestinal health, with a recommendation grade of B. Conclusion: Oligosaccharides are beneficial for the gastrointestinal health of infants and young children, providing a scientific basis for the development of infant formula. Further studies are needed to clarify the relationship between oligosaccharide dosage and infant intestinal health.
  • Food and Nutrition in China. 2026, (4): 0-0.
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    【Objective】 To systematically review and analyze the impact of lactoferrin on the gastrointestinal health of infants and young children. 【Methods】 Using ("lactoferrin") AND ("gut health" OR "intestinal health" “intestinal disease” “gut disease” “intestinal bacterial flora” “gut microflora” “intestinal microecology” “intestinal immune” “gut immunity” “intestine immunity” "intestinal barrier" "gut barrier" "brain-gut axis") as search terms, relevant Chinese and English literatures publicly published at home and abroad from January 2000 to September 2024 were searched in seven databases including PubMed, Embase, Medline, Cochrane, Chinese Biomedical Literature Service System, Wanfang Data Knowledge Service Platform, and China National Knowledge Infrastructure. The literatures were screened according to the inclusion and exclusion criteria. Referring to the evidence evaluation method recommended by the WHO and the GRADE evaluation system, the population evidence body was graded and comprehensively evaluated.【Results】 A total of 12 randomized controlled trials were included. Among them, 4 literatures reported that the supplementation of lactoferrin would not interfere with the intestinal health of infants and young children, and had little impact on the diversity and composition of the intestinal flora (evidence grade is good, comprehensive evaluation is grade B). Five literatures reported that the supplementation of lactoferrin was positively correlated with the intestinal health of infants and young children. However, 3 literatures obtained inconsistent conclusions. Among them, 2 literatures reported that the supplementation of lactoferrin did not reduce the late-onset infection rate, the severity of necrotizing enterocolitis in neonates, and the incidence of sepsis. One literature reported that the supplementation of bovine lactoferrin might increase the risk of antibiotic-associated diarrhea (evidence grade is good, comprehensive evaluation is grade B). 【Conclusion】 Lactoferrin is closely related to the intestinal health of infants and young children, with preliminary studies suggesting its potential benefits. Further high-quality clinical trials are needed to validate the specific effects of lactoferrin supplementation alone on intestinal health.
  • Food and Nutrition in China. 2026, (4): 0-0.
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    【Objective】 To systematically analyze the association between natural milk fat and intestinal health. 【Methods】 Literature search terms including "natural milk fat", "milk fat", "sn-2 palmitic acid", "intestinal health", "intestinal diseases", "intestinal microbiota", " intestinal micro-ecology ", "intestinal immunity", "intestinal barrier", and "brain gut axis". The relevant Chinese and English literature published at home and abroad from January 1, 2000 to September 30, 2024 were retrieved from seven databases including PubMed, Embase, Medline, Cochrane, China Biomedical Literature Service System, Wanfang Data Knowledge Service Platform and China National Knowledge Infrastructure. Screen the literature according to inclusion and exclusion criteria, and evaluate the evidence level and comprehensive evaluation of the population research evidence body based on the evidence evaluation method and GRADE evaluation system recommended by the World Health Organization (WHO).【Results】 A total of 1767 articles were retrieved in this study, including 1663 in English and 104 in Chinese. After removing duplicate literature and reading the title, abstract, and full text, a total of 9 articles that met the inclusion criteria were included, all of which were randomized controlled trials. Nine studies have shown that the content of natural milk fat (sn-2 palmitic acid) may be directly or indirectly related to intestinal health, and natural milk fat (sn-2 palmitic acid) may be beneficial for the intestinal health of infants and young children. 【Conclusion】 Natural milk fat is closely related to the intestinal health of infants and young children. Current research has initially revealed its potential health benefits, suggesting that increasing the content of natural milk fat (sn-2 palmitic acid) in formula milk powder may be beneficial for the intestinal health of infants and young children. Moreover, more high-quality studies are needed in the future to further clarify the specific effects of natural milk fat as an individual component on gut health.
  • Food and Nutrition in China. 2026, (4): 0-0.
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  • Food and Nutrition in China. 2026, (4): 0-0.
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    Abstract: 【Objective】: To analyze the current research status, research hotspots and cutting-edges of artificial intelligence (AI) in the field of nutrition management at home and abroad, and provide reference for more in-depth research in this field in the future. 【Method】: Use the visualization software Cite Space 6.4.R1 to analyze the relevant research on artificial intelligence in the field of nutrition management published in China National Knowledge Infrastructure, Wanfang, Weipu Database, and Web of Science core collection databases. The search time limit is to build the database until August 1, 2025. 【Result】: A total of 87 Chinese literature and 113 English literature were included. Artificial intelligence publishes fewer documents at home and abroad in the field of nutrition management, but overall it is on the rise. The country with the most documents is the United States (29 articles). Research hotspots mainly focus on the application of AI in recommendation systems, diet evaluation, and diet management. The cutting-edge research is nutrition management, diet evaluation, knowledge graph, and machine learning. Research trends are nutritional assessment monitoring and personalized dietary recommendations. 【Conclusion】: Artificial intelligence research in the field of nutrition management is increasing. In the future, Chinese researchers should focus on the research hotspots and cutting-edge trends in this field based on the domestic situation, strengthen inter-agency cooperation at home and abroad, strengthen interdisciplinary cooperation, enhance my country's international influence in this field, and promote the development of AI in the field of nutrition management.
  • Food and Nutrition in China. 2026, (4): 0-0.
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    Abstract: [Objective]: In order to explore the main factors affecting consumers' purchase of Yunnan walnut, and provide basis for in-depth understanding of the demand characteristics and laws of Yunnan walnut consumer market. [Method]: Based on 1430 valid questionnaire data collected nationwide, the binary logistic regression model was used to empirically analyze the factors of consumers' willingness to buy Yunnan walnut. [Result]: Regression analysis shows that consumers' education level of 10% has a positive effect on purchase intention; Product safety and quality, origin, brand awareness and recommendation of family and friends were positively significant at the 1% level; Nutritional value, taste and taste, discount promotion level of 5% are positive significant, while product price is negative significant at 1% level. Gender, age, monthly income, exquisite packaging, advertising and as gifts have no significant impact on consumers' willingness to buy walnuts. [Conclusion]: Product quality and safety,origin, brand awareness, recommendations from friends and family, and product price are the core factors affecting consumers' purchase. Nutritional value, taste, and discount promotion have a significant impact on consumers' purchase. Based on the research results, suggestions are put forward to enhance the market competitiveness and consumer power of Yunnan walnut, such as strengthening brand construction, optimizing product flavor, and implementing differential pricing strategies. Key words: Yunnan walnut; Purchase intention; Influencing factors; Logistic regression model
  • Food and Nutrition in China. 2026, (4): 0-0.
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    Objective To explore the public's knowledge and risk perception of prepared foods, and to propose strategies for food safety risk communication and popular science publicity of prepared foods. Methods A stratified proportional sampling method was adopted to conduct a questionnaire survey among the public aged 18-59 in Shanghai regarding their knowledge and cognition of prepared meal food safety and their risk perception. The chi-square test was used to compare intergroup differences in characteristic factors—including demographic factors, consumption factors, information factors, and risk factors—among groups with different knowledge and cognition levels and different risk perception levels. Stepwise linear regression analysis was employed to analyze the influencing factors of risk perception. Results A total of 1130 valid questionnaires were collected. The analysis results indicate that the public in Shanghai has a relatively low level of knowledge and cognition regarding prepared meals (51.70 ± 13.18 points), while their risk perception (71.86 ± 20.44 points) falls into an above-average range. Statistically significant differences were observed among different risk perception level groups in 15 aspects, including age, gender, occupation, marital status, children status, household income, household registration, place of residence, taste characteristics, risk experiences, food ingredient preferences, and cooking interest (all p < 0.05). Positive and neutral information types (B = -17.264 and B = -6.542, p < 0.001), middle age (40-49 years old) (B = -3.901, p < 0.001), no minor children (B = -4.016, p < 0.001), no prior risk experiences (B = -7.001, p < 0.001), insensitivity to the taste of fresh ingredients (B = -2.795, p = 0.04), as well as industrialized production (X1), no added preservatives (X2), and exclusion of clean vegetables (X5) in knowledge and cognition, were identified as negative influencing factors of risk perception (B = -0.114, B = -0.097, and B = -0.053, all p < 0.001). In contrast, non-governmental information release entities (B = 3.627, p < 0.001), food-related enterprises (B = 7.264, p = 0.021), and other occupations (B = 4.185, p < 0.001) were positive influencing factors of risk perception.Conclusion We should strengthen the public's understanding of knowledge regarding prepared foods in aspects such as production processes, preservation technologies, and quality and safety, enhance the public's scientific cognitive level of prepared foods, reduce the public's unreasonable risk perception of prepared foods, and provide a favorable public opinion environment for the high-quality development of the prepared food industry.
  • Food and Nutrition in China. 2026, (4): 0-0.
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    Abstract:Objective To test the applicability of the International Federation of Gynecology and Obstetrics (FIGO) nutrition checklist for early pregnant women in China. Methods In April 2023, first-trimester pregnant women (6–13+6 weeks) were recruited from Weifang Maternal and Child Health Hospital of Shandong Province, and the dietary status of participants in the past month was investigated via the validated dietary frequency questionnaire (FFQ). The FIGO nutrition score, DASH diet score, Mediterranean diet score (MDS), Diet Balance Index for Pregnancy (DBI-P) and Dietary Diversity Scores (DDS) are calculated to evaluate the dietary quality of pregnant women in the first trimester of pregnancy. The relationships between the FIGO nutrition score and other dietary indices were detected via the Spearman correlation coefficient. Result In total, 168 valid FFQs were collected. The median FIGO nutrition score is 3 (2-4). The consumption percentages of meat, vegetables and fruits, fish, dairy products, whole grains and snacks are 48.21%, 48.81%, 29.76%, 24.40%, 21.43% and 85.12%, respectively. The correlation coefficients between the FIGO nutrition score and DASH, MDS, DBI-P and DDS are 0.366 (P<0.001), 0.292 (P<0.001), -0.519 (P<0.001) and 0.565 (P<0.001), respectively.Conclusion The results of the present study revealed that FIGO nutrition scores are highly correlated with other dietary scores, confirming the applicability of the FIGO nutrition checklist in identifying diet and nutritional deficiencies in early pregnancy. The FIGO nutrition checklist can be used as a tool to screen the nutritional status of pregnant women in the first trimester.
  • Food and Nutrition in China. 2026, (4): 0-0.
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    Objective: To analyze the current status, hot topics, and development trends of nutritional research in peritoneal dialysis patients using Citespace. Methods: Relevant literature was retrieved from the China National Knowledge Infrastructure (CNKI) database from January 1, 2000, to July 1, 2025. Citespace 6.4R1 was used to analyze the number of publications, authors, institutions, and keywords. Results:A total of 936 articles were included. The number of publications showed a fluctuating upward trend before 2020 and a slight decline in recent years after 2020. A core group of authors has begun to form, but the collaborative network remains loose. Research institutions are primarily large comprehensive hospitals or universities, with inter-institutional collaboration requiring further strengthening. Research hotspots are primarily concentrated in areas such as “assessment and diagnosis of malnutrition,” “inflammatory states and nutrition,” “nutritional intervention,” “quality of life,” “protein-energy wasting (PEW),” “traditional Chinese medicine,” and “gut microbiota”; Research frontiers have evolved from early focus on methods for assessing malnutrition to exploring the interaction between nutrition and inflammation, personalized and refined targeted nutritional management, remote home-based nutritional intervention models, and improvements in long-term outcomes. Conclusion: Currently, domestic researchers in this field are gradually shifting from a single treatment model to an integrated treatment model that combines nutrition, nursing, psychology, and lifestyle. Future research should deepen multi-center collaboration and further explore personalized nutritional support programs and their impact on patient outcomes.
  • Food and Nutrition in China. 2026, (4): 0-0.
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    【 Objective】 To determine the glycemic index (GI) of mixed meals with different dietary patterns, analyze the correlation and consistency between GI values obtained via the Flash Glucose Monitoring (FGM) system and venous blood sampling, and explore the feasibility of using FGM for GI determination of mixed meals. 【Methods】 A total of 17 healthy adults with normal glucose tolerance were enrolled and underwent five meal tests: two with a reference food (50 g glucose) and three with different mixed meals (each containing 50 g carbohydrates), including one without vegetables, one with a single vegetable, and one with multiple vegetables. Following the health industry standard "WS/T 652-2019 Methods for Determination of Glycemic Index of Foods," venous blood was collected over 3 hours postprandially to calculate GI. Simultaneously, continuous glucose data from FGM were collected. Consistency was analyzed for 544 paired FGM-venous glucose values, and correlation and agreement were assessed between the GI values derived from the two methods. 【Results】 Based on venous blood measurements, the GI values of the three mixed meals were 63 (medium GI), 55 (low GI), and 33 (low GI), respectively. No statistically significant difference was found between the GI values of the same mixed meal measured by venous blood and FGM (p > 0.05). Analysis of 544 paired glucose values showed that Clarke error grid analysis placed 98.35% of the data points in zones A and B, while Parkes error grid analysis placed 99.45% in zones A and B. The mean absolute relative difference (MARD) was 12.7%. Pearson correlation analysis indicated a significant correlation between GI values obtained by the two methods (r = 0.711, p < 0.01). Bland-Altman analysis showed limits of agreement ranging from -29.64 to 31.58. 【Conclusion】 The use of FGM for determining the GI of mixed meals shows certain feasibility.
  • Food and Nutrition in China. 2026, (4): 0-0.
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    The freshness of raw milk is critical for ensuring the quality and safety of dairy products. This study investigates the potential of using electronic nose (e-nose) and electronic tongue (e-tongue) technologies to monitor freshness changes during storage. Key freshness indicators such as total viable count (TVC), pH, and acidity were measured, alongside sensor data from the e-nose and e-tongue systems. Principal component analysis (PCA) and sensor loading analyses revealed that the e-nose effectively detected significant changes in volatile organic compounds (VOCs), while the e-tongue identified alterations in taste-related compounds such as bitterness and umami. Notably, sensors W1C, W5S, W3C, and bitterness were identified as critical for freshness detection. The combined use of e-nose and e-tongue provided a robust method for distinguishing milk stored for different durations. These findings highlight the applicability of sensor-based technologies in dairy freshness monitoring and quality control.
  • Food and Nutrition in China. 2026, (4): 0-0.
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    【Objective】To investigate the fat content and distribution in restaurant and home-cooked dishes in China, providing evidence for oil-reduction interventions.【Methods】In eight cities, 15 Chinese restaurants were selected from urban and suburban areas in each city, with eight popular dishes sampled per restaurant. Additionally, 30 daily home-cooked dishes were collected from urban and suburban areas in each city. All samples were sent to a third-party laboratory for fat content analysis. A total of 1,914 restaurant dishes and 492 home-cooked dishes were included in the final analysis.【Results】The median fat content of restaurant dishes (8.60g/100g) is higher than that of home-cooked dishes (6.80g/100g). The proportion of fat content in the inedible parts (oil soup) of restaurant dishes (12.28%) is higher than that of home-cooked dishes (7.80%). Both restaurant and home-cooked dishes prepared by frying/frying/grilling have higher fat content than those cooked by other methods. For restaurant dishes, the proportion of fat content in the inedible parts (oil soup) of dishes cooked by boiling is higher than that of those prepared by other cooking methods.In terms of dish types, both restaurant and home-cooked meat hot dishes have higher fat content and a higher proportion of fat in inedible parts (oil soup) than other types of dishes.The fat content of dishes cooked by people with a college education or above is lower than that of other groups. 【Conclusion】 Both restaurants and households should reduce using cooking oil and high-fat foods, and avoiding oily soup during meals can help reduce fat intake.
  • Food and Nutrition in China. 2026, (4): 0-0.
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    【Objective】This paper comprehensively reviews recent progress in Synthetic biology strategies to boost astaxanthin yields in Haematococcus pluvialis.【Method】Drawing on published studies, we examined key metabolic pathway modifications—including gene editing of critical enzymes (PDS, BKT)—and chassis cell optimization techniques, while assessing their outcomes.【Result】Here are the key findings: 1 Metabolic Pathway Engineering: Optimizing promoters, codon usage, and chloroplast overexpression of pds increased astaxanthin production by up to 67% versus wild-type strains. 2 Gene Expression Tuning: Replacing reporter genes with endogenous sequences to enhance bkt expression achieved 7.96 mg/g DW astaxanthin. 3 Efficient Transformation: Developed Agrobacterium-mediated, protoplast-based, and chloroplast transformation systems, significantly improving genetic manipulation efficiency. 4 Cell Wall Modulation: Knocking down the hpoch1 mannan synthase gene increased cell rupture rates by 58%, facilitating extraction. 5 Heterotrophic Growth: Introducing the hup1 hexose transporter enabled astaxanthin synthesis under dark conditions, expanding cultivation flexibility.【Conclusion】For fure directions, genetic engineering has successfully addressed natural production bottlenecks in H. pluvialis through pathway enhancement and chassis refinement. Further advances in multigene editing, novel chassis design, and metabolic network modeling will unlock its full potential for food, nutraceutical, and industrial applications.
  • Food and Nutrition in China. 2026, (4): 0-0.
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    Abstract:【Objective】 The aim of this study was to investigate the potential causal effect of fruit intake on coronary artery disease, pulmonary embolism, hypertension, atrial fibrillation and type 2 diabetes mellitus.【Method】Using Mendelian randomization, the exposure was fruit intake and the outcomes were five common cardiovascular diseases (coronary heart disease, pulmonary embolism, hypertension, atrial fibrillation, and type 2 diabetes);using pooled Genome-Wide Association Study (GWAS) data from the UK Biobank with single nucleotide polymorphisms (SNPs) as an instrumental variable, five methods of two-sample Mendelian randomization (TSMR) were performed: the MR-Egger, weighted median ( Weighted median), inverse variance weighting (IVW), simple mode and weighted mode were used for two-sample Mendelian randomization (TSMR) analyses, with inverse variance weighting (IVW) as the main analytical method to explore the potential Causality. Cochran’s Q was used to detect heterogeneity. Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO) test and MR-Egger regression were used to detect horizontal pleiotropy; the robustness of the results was analysis by using the ‘leave-one-out’ method; use of funnel plots to assess symmetry.【Result】The results of IVW analyses showed no significant causal association between fruit intake and coronary artery disease, hypertension, atrial fibrillation and type 2 diabetes mellitus; Dried fruit intake was not significantly causally associated with pulmonary embolism; whereas fresh fruit intake may increase the risk of pulmonary embolism [advantage ratio (OR) = 1.0154, 95% confidence interval (CI): 1.0014-1.0295, p = 0.0307]; The results of the other four methods (MR-Egger, Weighted median, Simple mode, Weighted mode) were similar to the results of the IVW method. Sensitivity analyses showed that there was no heterogeneity or horizontal pleiotropy in the results of the MR analyses, and leave-one-out method analyses showed that the MR results were robust.【Conclusion】This study suggests that there may be a potential causal relationship between fresh fruit intake and pulmonary embolism.
  • Food and Nutrition in China. 2026, (4): 0-0.
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    【Objective】This study aims to analyze the association between dietary carotenoid intake and depressive symptoms in individuals with chronic constipation.【Methods】Based on data from the 2005-2010 National Health and Nutrition Examination Survey , 838 adult patients with chronic constipation were included. Weighted logistic regression, subgroup analysis, and restricted cubic spline were used for investigation.【Results】 After comprehensive adjustment for covariates, compared with the lowest tertile, the highest tertile of total dietary carotenoids (OR = 0.36, 95% CI: 0.17-0.74, dietary lycopene (OR = 0.31, 95% CI: 0.14-0.68), and total lycopene (OR = 0.30, 95% CI: 0.14-0.65) was associated with a lower risk of depression (P for trend all <0.05).Subgroup analysis showed that the highest quartile (Q3) of dietary lycopene and total lycopene was significantly and inversely associated with depression risk in the "20-50 years" group, males, those with high school education or above, those with a specific Poverty Income Ratio (PIR), non-obese individuals (BMI<30 kg/m2), and those with lower dietary fiber intake. The highest intake of total dietary carotenoids was significantly and inversely associated with depression risk in the "20-50 years" group, females, those with high school education, those with a higher PIR, non-obese individuals (BMI<30 kg/m2), and those with lower dietary fiber intake. RCS analysis further revealed a nonlinear U-shaped relationship between the intake of total dietary carotenoids and dietary lycopene and depression risk (P-nonlinear = 0.007 and 0.031, respectively).【Conclusion】Among patients with chronic constipation, higher intake of carotenoids (especially lycopene) is associated with a lower risk of depression. RCS indicates a nonlinear U-shaped relationship between the intake of total dietary carotenoids and dietary lycopene and depression risk, suggesting that moderate dietary lycopene intake may have potential significance for the mental health of this population. The causal relationship requires further validation by prospective studies.